In the 17th century, it wasn't uncommon to hear of women who were accused of being witches. One of the most famous cases, the Salem Witch Trials may be due to ergotism. It's a disease that occurs after consuming bad rye or other cereals. It can cause bad physical pain along with mania, delirium, psychosis, and melancholia which affect the mind. Most of the same symptoms were described in the women accused of witchcraft.