I loved Resident Evil 4 on Gamecube, and I couldn't wait for the Wii version.
The new Wii controls are much easier than the Gamecube ones. It's pretty easy to move around, and aim freely. However Capcom thinks so too, so they added more enemies to make the game tougher. I like my cakewalks Capcom!
Even the interactive cut-scenes have Wii controls in mind. They work fairly well.
Plus all the content from the PS2 version is available on the Wii disc, which makes this really the best version to have.