With the end of World War I and Wilson's 2nd term coming to a close, Democrats nominated Governor James M. Cox of Ohio.
Democrats chose distant cousin to Teddy Roosevelt, and future president Franklin Delano Roosevelt as Cox's running mate.
Republicans nominated Senator Warren G. Harding as their nominee. Which pitted two men from the state against each other.
3rd party support was pretty slim this election. The most notable was the Socialist Party's Eugene V. Debs who campaigned from prison. He was sentenced for being against the war draft.
While Harding ignored Cox for most of the campaign, he was trying more to campaign against Woodrow Wilson's polices than his opponent. He called for "A return to normalcy" and was extremely critical of World War I and the Treaty of Versailles. Wilson's failed promises to please Irish-Americans backfired against his party and many instead supported Harding.
America's unpopular opinion over Wilson' foreign policy seemed to be the easiest way to victory for Harding. He managed to get 37 states versus Cox's 11 (all southern) states. Harding got 404 electoral votes versus Cox's 127.